I am beginning to think that the NIH challenge grants are a cunningly disguised trap. The NIH is giving out $200 million for grants that can be up to $1 million apiece and do not require preliminary data. This set-up could generate a lot of applications.
I think that it might make more sense to put that effort into a very solid R01 grant proposal and try to win longer term funding under less pressure of time and with more opportunity to generate productivity.
But, of course, the siren call of "no pilot data" is certainly sounding in my ears too!
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